Osteoclast, large multinucleated cell responsible for the dissolution and absorption of bone. Bone is a dynamic tissue that is continuously being broken down and restructured in response to such influences as structural stress and the body's requirement for calcium. The osteoclasts are th Osteoklaster är en cell från immunförsvaret som inte försvarar kroppen mot inkräktare, utan istället bryter ned (onödig) benvävnad.. De utvecklas från monocyt-makrofaglinjens stamceller, har flera cellkärnor samtidigt och finns i all benvävnad i urgröpningar kallade Howships lakuner.På undersidan har deras cellmembran en räfflad yta med gropar som påminner om mikrovilli Osteoclasts form a seal around a resorption area by binding their integrins with a bone protein, vitronectin. The ruffled border incorporates a vacuolar-type H + pump that acidifies the extracellular area beneath the osteoclast. Lysosomal proteases and acid phosphatases are released by the osteoclast to break down the organic matrix Osteoclast. The osteoclast is a myeloid-derived polykaryon uniquely endowed with the capacity to degrade the organic and inorganic matrices of bone. From: International Review of Cell and Molecular Biology, 2013. Related terms: Bisphosphonates; Ligand; Eicosanoid Receptor; Osteoprotegerin; Bone Resorption; Apoptosis; Parathyroid Hormone; RANKL; Protei Osteoclasts are large multinucleated cells with a myeloid lineage, which have the function of clearing away mineralized and calcified constituents of the bone matrix which are aged or damaged.

Osteoclast cell Britannic

Om Osteoclast AB. Osteoclast AB är verksam inom annan allmän öppen hälso- och sjukvård, ej primärvård. Bolaget är ett aktiebolag som varit aktivt sedan 2015. Osteoclast AB omsatte 343 000 kr senaste räkenskapsåret (2020) Interactions between osteoclast precursors and bone-forming cells are believed to control osteoclast differentiation under most circumstances, preserving bone architecture over many cycles of bone replacement. Publication types Research Support, U.S. Gov't, P.H.S.. osteoclast a multinucleate ameoboid cell that breaks down bone during growth and remodelling. (also called Chomdrioclast ) same kind that breaks down cartilage in the transformation to bone Hitta perfekta Osteoclast bilder och redaktionellt nyhetsbildmaterial hos Getty Images. Välj mellan premium Osteoclast av högsta kvalitet The second film in the bone biology series describes the role and functions of the cells responsible for breaking down bone tissue (osteoclasts) and building..

Definition. Osteoblast: An osteoblast is a bone-forming cell that is derived from the mesenchymal osteoprogenitor cells and is involved in the bone remodeling processes. Osteoclast: An osteoclast is a type of bone cell that is responsible for the bone resorption Osteoclasts. Unlike osteoblasts, osteoclasts contain more than one nucleus. They are large cells produced by the fusion of several smaller ones. Osteoclasts travel over the surface of the bone matrix and secrete acids and enzymes to disintegrate it, forming a little pit on the surface of the bone Osteoclast: A cell that nibbles at and breaks down bone and is responsible for bone resorption. Osteoclasts are large multinucleate cells (cells with more than one nucleus) that differentiate from another type of cell called a macrophage

Osteoblasts (from the Greek combining forms for bone, ὀστέο-, osteo-and βλαστάνω, blastanō germinate) are cells with a single nucleus that synthesize bone.However, in the process of bone formation, osteoblasts function in groups of connected cells.Individual cells cannot make bone. A group of organized osteoblasts together with the bone made by a unit of cells is usually. This fourth film in our bone biology series focuses on the link between the protein RANK ligand and how it signals the process of bone tissue breakdown Osteocytes are cells that form the bones themselves, osteoblasts are responsible for the formation of new osteocytes, whereas osteoclasts are responsible for the resorption of old bone matter. Thus, between them, the three types of bone cells regulate the formation, sustenance, and decay of bones Medical Definition of osteoclast. 1 : any of the large multinucleate cells closely associated with areas of bone resorption (as in a fracture that is healing) — compare chondroclast. 2 : an instrument for performing osteoclasis Excessive osteoclast formation and function are considered as the main causes of bone lytic disorders such as osteoporosis and osteolysis. Therefore, the osteoclast is a potential therapeutic target for the treatment of osteoporosis or other osteoclast-related diseases. Helvolic acid (HA), a mycotox

osteoclast translation in English-Swedish dictionary. Cookies help us deliver our services. By using our services, you agree to our use of cookies (Submitter supplied) Balanced osteoclast differentiation is crucial in maintaining skeleton health through life. Receptor activator of nuclear factor kappa-Β (RANK) is indispensable for OCs normal development in vivo and for the in vitro fusion of circulating progenitor cells into OCs What does osteoclast mean? A large multinucleate cell found in growing bone that resorbs bony tissue, as in the formation of canals and cavities Now, a team of researchers in China and Australia has shown that SARS-CoV-2 infection can affect bone marrow macrophage (BMM)-to-osteoclast differentiation, which may impact the skeletal system Identification of osteoclast and osteoblast gene signatures. The bone was centrifuged to remove loosely adherent marrow; the remaining bone sample (bone and cells on the bone surface, e.g.

Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses An osteoclast (from Ancient Greek ὀστέον (osteon) 'bone', and κλαστός (clastos) 'broken') is a type of bone cell that breaks down bone tissue.This function is critical in the maintenance, repair, and remodelling of bones of the vertebral skeleton.The osteoclast disassembles and digests the composite of hydrated protein and mineral at a molecular level by secreting acid and a. An instrument used in surgical osteoclasis. noun. 0. 0. A specialized bone cell that absorbs bone, allowing for the deposition of new bone and maintenance of bone strength. Osteoclasts secrete enyzmes that dissolve the matrix of old bone tissue and acids that dissolve bone salts, which contain calcium and phosphorus osteoclasts (bone-destroying cells) and bone resorption on human spongy bone (magnification x250). osteoclasts are giant multinucleate cells that cause bone resorption (removal) thus functioning in bone remodelling and release of calcium. also shows osteoc - osteoclast stock pictures, royalty-free photos & images Osteoblast and Osteoclast Markers. Bone homeostasis is dependent on the balance of deposition by osteoblasts and resorption by osteoclasts. This dynamic process is responsible for the continuous remodeling of bone tissue and is crucial for maintenance of bone size, shape, and integrity

osteoclastic: ( os'tē-ō-klas'tik ), Pertaining to osteoclasts, especially with reference to their activity in the absorption and removal of osseous tissue Osteoclast Aktiebolag - Org.nummer: 559001-6738. På Bolagsfakta.se hittar du kontakt-och företagsinformation, nyckeltal, lön till VD & styrelse m.m Kontaktuppgifter till Osteoclast AB STOCKHOLM, adress, telefonnummer, se information om företaget K. Tsukii u. a.: Osteoclast differentiation factor mediates an essential signal for bone resorption induced by 1 alpha,25-dihydroxyvitamin D3, prostaglandin E2, or parathyroid hormone in the microenvironment of bone. In: Biochem Biophys Res Commun. 246, 1998, S. 337-341. Weblinks. Abbildung der Osteoklastentätigkei Osteoclast differentiation was induced by culturing bone marrow-derived macrophages in the presence of RANKL and macrophage colony‐stimulating factor (M‐CSF), and was evaluated by counting tartrate‐resistant acid phosphatase-positive multinucleated cells

The mechanisms behind osteoclast fusion are similarly poorly understood, and these data suggest GBP-mediated regulation of cell fusion may be important for inflammatory bone remodeling Osteoclast Mmp9 and Mmp14 exert codependent control of bone type I collagenolysis Given that Mmp9 / Mmp14 DKO osteoclasts exhibit defects in collagenolytic activity and that type I collagen.. Early immature proliferative mononuclear phagocytic cells, also called osteoclast precursors, enter the blood circulation under the action of chemical factors and then enter the bone structure cavity under the action of signal factors released by basal multicellular units. Under the stimulation of various chemical factors, transcription factors, cytokines, and other signaling factors, they are. The prefix osteo relates to bones. Ossein is the actual substance that comprises bones. Retrieved from https://monsterlegends.fandom.com/wiki/Osteoclast?oldid=94858 . Categories Osteoclast differentiation is stimulated by TRANCE/TNFSF11 via its receptor, RANK/TNFRSF11, expressed on pre-osteoclast cells. However, under normal physiological conditions, these signals are not sufficient and new evidence implies the existence of other mediators

osteoclast. [ ŏs ′tē-ə-klăst′ ] A specialized bone cell that absorbs bone, allowing for the deposition of new bone and maintenance of bone strength. Osteoclasts secrete enyzmes that dissolve the matrix of old bone tissue and acids that dissolve bone salts, which contain calcium and phosphorus Osteoclast AB har 1 annan verksamhet i Sverige. Det som ligger närmast Stockholmskontoret är Osteoclast AB i Stockholm

Patients with osteoclast-rich osteopetrosis caused by mutations in osteoclast a3-V-ATPase or chloride channel ClC-7 have unaltered or even increased bone formation despite reduced bone resorption , supporting the importance of osteoclasts themselves in the coupling process Osteoclasts are found only on the surface of calcified matrix, and although the exact process of osteoclast development in vivo remains mostly an enigma, it is widely believed that the bone marrow is the site of osteoclast generation

This osteoclast-mediated bone destruction was protected by the anti-PD-1 treatment or Pd1 deletion. Second, TRAP staining in tumor-bearing BM and serum CTX-I analysis in serum demonstrated functionality of PD-1 blockade in suppressing osteoclast formation and osteoclast overactivation Osteoclast. Overview. This picture shows a normal osteoclast. It is a large cell with separately identifiable, multiple nuclei. Osteoclasts are needed to repair bone. Review Date 2/26/2020. Updated by: C. Benjamin Ma, MD, Professor, Chief, Sports. An osteoclast is a large cell that is characterized by multiple nuclei and a cytoplasm with a homogeneous, foamy appearance. This appearance is due to a high concentration of vesicles and vacuoles. At a site of active bone resorption, the osteoclast forms a specialized cell membrane, the ruffled border, which touches the surface of the bone tissue Since their identification in 1873 (Kolliker, 1873), the origin of osteoclasts has been controversial; however, in the 1970s, their haematopoietic origin was confirmed by Walker's pioneering experiments, as transplantation of bone marrow and spleen cells from wild-type mice restored bone resorption in osteoclast-deficient osteopetrotic mice, demonstrating that hematopoietic tissues produce migratory cells (osteoclast progenitors) that are essential for the resorption of hard tissue (Walker.

Osteoklast - Wikipedi

  1. This process of bone resorption followed by formation is a delicate balance between two cell types, the osteoclast and the osteoblast. From the Cambridge English Corpus The end result is a 'vicious cycle' whereby complex multi-directional interactions among tumour cells, osteoblasts and osteoclasts lead to ever-increasing bone destruction and tumour growth
  2. Osteoclast progenitor cells are recruited from haematopoietic compartments, and then proliferate and differentiate toward mature osteoclasts. During this multistep differentiation process postmitotic osteoclast precursors progressively express osteoclast-associated markers, such as calcitonin receptor and tartrate-resistant acid phosphatase, as they lose some of their macrophage characteristics
  3. g activity of osteoclasts was also inhibited by the anti-Siglec-15 antibody
  4. Induces bone resorption, acting probably through a signaling cascade which results in the secretion of factor(s) enhancing osteoclast formation and activity
  5. e its molecular mechanism on receptor activator of NF-κB ligand (RANKL)-induced osteoclastogenesis in mouse bone marrow-derived monocyte.
  6. Review and cite OSTEOCLAST protocol, troubleshooting and other methodology information | Contact experts in OSTEOCLAST to get answer

Osteoclast - an overview ScienceDirect Topic

  1. Osteoclast-like giant cells (OLGCs) are a rare histologic finding within a tumor of the breast. Although there has been discussion as to the pathogenesis and prognosis related to this finding, our understanding of its significance remains inconclusive
  2. Cudratrixanthone U (CTU) is a prenylated xanthone compound isolated from Maclura tricuspidata Bureau (Moraceae). Prenylated xanthones have been reported to exhibit a variety of biological activities. However, the effects of prenylated xanthone on osteoclast differentiation and function are still unclear. Excessive bone resorption by osteoclasts is considered a major cause of diseases such as.
  3. The osteoclast is a giant cell that resorbs calcified matrix by secreting acids and collagenolytic enzymes. The molecular mechanisms underlying metabolic adaptation to the increased biomass and energetic demands of osteoclastic bone resorption remain elusive
  4. Upon stimulation by RANKL, osteoclast precursor cells such as bone marrow‐derived macrophages (BMMs) become large, polarized, multinucleated cells with an F‐actin ring around ruffled borders through which the cells release hydrogen ions, hydrolytic enzymes, and matrix metalloproteases (MMPs) that are required for bone resorption. 3 These enzymes are induced by RANKL stimulation and.
  5. Osteocalcin (OCN) was the most abundant noncollagen protein and considered as an endocrine factor. However, the functions of Undercarboxylated osteocalcin (ucOCN) on osteoclast and bone resorption are not well understood. In the present study, preosteoclast RAW264.7 cells and bone marrow mononuclear cells (BMMs) were treated with ucOCN purified from prokaryotic bacteria
  6. Osteoclast di˜erentiation byRAGnaling pathways Nobuyuki Udagawa1,2 · Masanori Koide2 · Midori Nakamura1,2 · Yuko Nakamichi 2 · Teruhito Yamashita 2 · Shunsuke Uehara1 · Yasuhiro Kobayashi 2 · Yuriko Furuya 3 · Hisataka Yasuda3 · Chie Fukuda4 · Eisuke Tsuda4 Received: 19 July 2020 / Accepted: 22 September 202
  7. Osteoclast definition: a surgical instrument for fracturing bone | Meaning, pronunciation, translations and example

L⁄OPG osteoclast program. Not surprisingly, excessive osteoclast activity induced by the inflammatory process will exacerbate root resorption. On the other hand, orthodontically induced root resorption may be associ-ated with defective alveolar resorption and⁄or turnover along with tooth movement or force application Osteoblast vs Osteoclast Center Osteoclasts travel over the surface of the bone matrix and secrete acids and enzymes to disintegrate it, forming a little bit on the surface of the bone. In simple words, an osteoblast builds the bone, whereas an osteoclast eats up the bone so that it can be reshaped into a stronger and resilient load-bearing structure

Define osteoclast. osteoclast synonyms, osteoclast pronunciation, osteoclast translation, English dictionary definition of osteoclast. n. 1. A large multinucleate cell found in growing bone that resorbs bony tissue, as in the formation of canals and cavities. 2. An instrument used in.. Osteoclast (OCL) ₪ The osteoclast (OCL) is the primary bone resorbing cell. ₪ The osteoclast were first recognised in 1873 by Albert Kolliker as a multinuclear cell that digest bone. ₪ It is a highly specialized multinucleated cell whose primary function is to help in the control of calcium homeostasis. www.indiandentalacademy.com 8 Media in category Osteoclast The following 20 files are in this category, out of 20 total. Bone degrading cells - Osteoclast precursors -- Smart-Servier.jpg 10,240 × 5,760; 1.48 M Adriana Plesa, Pierre Sujobert; This is not an osteoclast, Blood, Volume 128, Issue 15, 13 October 2016, Pages 1993, https://doi.org/10.1182/blood-2016-06-7223 Generate osteoclast specific Raptor deletion mice (Raptor fl/fl; Ctsk-cre, hereafter Rap Ctsk) by mating Raptor fl/fl mice with Ctsk-cre mice. Use the Raptor fl/fl mice as the WT control in this study. Have a container with ice to keep isolated bone. Prepare culture medium

Osteoclasts, the only cells with bone resorption functions in vivo, maintain the balance of bone metabolism by cooperating with osteoblasts, which are responsible for bone formation. Excessive activity of osteoclasts causes many diseases such as osteoporosis, periprosthetic osteolysis, bone tumors, and Paget's disease. In contrast, osteopetrosis results from osteoclast deficiency However, osteoclast formation was severely reduced at 2 dphs, and only single ctsk-positive osteoclasts were detectable in the vertebral column of cxcl9l mutants, while wild-type siblings had abundant osteoclasts (Fig. 5 C and D) Ejemplo de cómo usar osteoclast en una oración de Cambridge Dictionary Lab ODF = Osteoclast differentiering faktor Letar du efter allmän definition av ODF? ODF betyder Osteoclast differentiering faktor. Vi är stolta över att lista förkortningen av ODF i den största databasen av förkortningar och akronymer. Följande bild visar en av definitionerna för ODF på engelska: Osteoclast differentiering faktor

Caption: Osteoclast cells (red) carve a path through a knee joint (purple and white), enabling a blood vessel to supply the cells (yellow) needed to build new bone. Credit: Paul R. Odgren, University of Massachusetts Medical Schoo Definition of osteoclast in the Definitions.net dictionary. Meaning of osteoclast. What does osteoclast mean? Information and translations of osteoclast in the most comprehensive dictionary definitions resource on the web osteoclast - WordReference English dictionary, questions, discussion and forums. All Free Osteoclasts are the only cells that perform bone resorption. Noncoding RNAs (ncRNAs) are crucial epigenetic regulators of osteoclast biological behaviors ranging from osteoclast differentiation to bone resorption. The main ncRNAs, including miRNAs, circRNAs, and lncRNAs, compose an intricate network that influences gene transcription processes related to osteoclast biological activity

Besides, we found significantly increased of osteoclast-specific markers, such as NFAT2, TRAP, CTSK and MMP-9 in the RAW264.7 cells treated with KPC-exosomes. Similarly, we isolated the BMM cells in the C57 femur and evaluated the effect of KPC-exosomes on the differentiation and activation of BMM cell Osteoclast‐mediated inflammatory bone resorption is a major cause of skeletal diseases, such as rheumatoid arthritis and periodontitis. 32, 33 However, the mechanisms regulating osteoclastogenesis and bone resorption under inflammatory conditions are complex and have not been well elucidated Download Citation | On Jan 1, 2002, Kalervo Väänänen and others published Osteoclast Function | Find, read and cite all the research you need on ResearchGat Dynamin‐related protein 1 (DRP1) is a mitochondrial membrane GTPase and regulates mitochondrial fission. In this study, we found that the cytokine RANKL increased the expression of DRP1 and its receptor proteins, Fis1, Mid49, and Mid 51, during osteoclast formation in mouse bone marrow‐derived macrophages Other articles where Howship lacunae is discussed: osteoclast: on the bone's surface, called Howship lacunae; the lacunae are thought to be caused by erosion of the bone by the osteoclasts' enzymes. Osteoclasts are formed by the fusion of many cells derived from circulating monocytes in the blood. These in turn are derived from the bone marrow

What are Osteoclasts? - News-Medical

Moreover, EPS624 induced IL-10 production in osteoclast precursors in a TLR2-dependent manner, although IL-10 was dispensable in the EPS624-mediated inhibition of osteoclast formation. In addition, EPS624-producing B. longum 35624® partially prevented bone loss in Ovx mice when administered by oral gavage Osteoclast differentiation and activation. Nature. 2003;423:337-42 22. Armstrong AP, Tometsko ME, Glaccum M, Sutherland CL, Cosman D, Dougall WC. A RANK/TRAF6-dependent signal transduction pathway is essential for osteoclast cytoskeletal organization and resorptive function. The Journal of biological chemistry. 2002;277:44347-56 23 The osteoclast differentiation inhibitor for inhibiting the differentiation of precursor cell of the osteoclast to the osteoclast contains the above protein. 例文帳に追加. 破骨細胞の前駆細胞が破骨細胞へ分化することを阻害する破骨細胞分化阻害剤は、上記タンパク質を含む。 - 特許

Osteoclast Aktiebolag,559001-6738 - På allabolag.se hittar du , bokslut, nyckeltal, styrelse, Statu Osteoclast Cells. These are the cells that are primarily responsible for dissolving bone tissue, also known as resorption. They do not arise from osteoprogenitor cells; instead, white blood cells that normally have immune system function (monocytes) fuse together to create the osteoclasts Normal osteoclasts resorb bone by secretion of acid and proteases. Recent studies of patients with loss of function mutations affecting either of these processes have indicated a divergence in osteoclastic phenotypes. These difference in osteoclast phenotypes may directly or indirectly have secondary effects on bone remodeling, a process which is of importance for the pathogenesis of both.

Osteoclast: Definition, Function & Formation - Video

Download Citation | The Osteoclast | The osteoclast is the cell that resorbs bone. It has been known for many years that it is formed from cells of the mononuclear phagocyte system,. Remarkably, although osteoclast numbers were increased in mTsKO mice, BMMs from mTsKO mice were unable to form TRAP‐positive osteoclast‐like cells following stimulation with RANKL (Fig. 5A, B). Moreover, mRNA levels for osteoclast differentiation‐related genes were dramatically decreased in these mutant groups (Fig. 5C) The use of osteoclast inhibitors in patients with MM will be presented here. The role of these agents in the management of hypercalcemia and bone metastases from other malignancies is presented separately, as are more details regarding the side effects associated with each agent

solunetti: Osteoklast, osteoklasti, osteoclas

Hyperactive osteoclasts (OCs) are a fundamental reason for excessive bone resorption and consequent osteoporosis that lead to one-third of the patients sustaining a fracture. OCs, with the help of acidifying vesicles containing vacuolar-type H+-ATPase (V-ATPase), transport cytoplasmic protons into a resorpt The instructive capabilities of extracellular matrix-inspired materials for osteoprogenitor differentiation have sparked interest in understanding modulation of other cell types within the bone regenerative microenvironment. We previously demonstrated that nanoparticulate mineralized collagen glycosaminoglycan (MC-GAG) scaffolds efficiently induced osteoprogenitor differentiation and bone. The osteoclast precursors were subsequently stimulated with conditioned media from the 4T1-derived populations, which exhibited the most-pronounced difference in osteoclast numbers between control and ABCC5 knockdown breast cancer cells in vivo (Figure 5) Osteoclast: | | | |Osteoclast| | | | | |||... World Heritage Encyclopedia, the aggregation of the largest online encyclopedias available, and the most definitive. Sakamuri V. Reddy, PhD Professor & Director, Osteoclast Center. In 1988, Dr. Reddy obtained his PhD in Biochemistry from S.V. University, India. He then joined the University of Texas Health Science Center at San Antonio (UTHSCSA) as a postdoctoral fellow and advanced to the rank of associate professor in the department of medicine/hematology, UTHSCSA

Bone Histology - Embryology

Osteoblast - Wikipedi

Multinucleation is a hallmark of osteoclast maturation. The unique and dynamic multinucleation process not only increases cell size but causes functional alterations through reconstruction of the cytoskeleton, creating the actin ring and ruffled border that enable bone resorption. Our understanding of the molecular mechanisms underlying osteoclast multinucleation has advanced considerably in. If you haven't solved the crossword clue osteoclast yet try to search our Crossword Dictionary by entering the letters you already know! (Enter a dot for each missing letters, e.g. P.ZZ.. will find PUZZLE.) Also look at the related clues for crossword clues with similar answers to osteoclast Contribute to Crossword Clue Glucocorticoids increase osteoclast lifespan → increased bone absorption; Estrogen has a positive effect on bone balance because it inhibits osteoclast formation and activation and increases OPG formation. Bone healing [8] Fractures occur when bones are strained beyond their maximum load. Fractures can heal in two different ways. Primary bone. The osteoclast is the sole cell that resorbs bone and is central in pathologic situations, where bone destruction is intricately involved. Osteosarcoma cells are of the osteoblastic lineage, the latter of which is characterized by cells secreting the osteoclast-inducing factor, receptor activator of nuclear factor-κB ligand What Is the Difference Between Osteoblast and Osteoclast? By Staff Writer Last Updated Apr 8, 2020 4:46:17 AM ET. Ian Walton/Getty Images Sport/Getty Images. Osteoblasts and osteoclasts are types of cells the human body uses to repair broken bones

Pathology Outlines - Poorly differentiated variantHistology of the tumor consists of osteoclast-like giant

A giant osteoclast was defined as one having at least three of the following characteristics: more than eight nuclear profiles (two-dimensional images of a section taken through three-dimensional. Osteoclast inhibitors (also called antiresorptive agents), such as bisphosphonates and denosumab, significantly reduce both the frequency and time to onset of skeletal-related events (SREs) in patients with bone metastases from a wide variety of cancer types Inflammatory bone diseases, including rheumatoid arthritis, periodontitis and peri-implantitis, are associated not only with the production of inflammatory cytokines but also with local oxidative status, which is defined by intracellular reactive oxygen species (ROS). Osteoclast differentiation has been reported to be related to increased intracellular ROS levels in osteoclast lineage cells Regulation of osteoclast formation by toll-like receptors 2 and 5. 2012 (Engelska) Ingår i: Bone, ISSN 8756-3282, E-ISSN 1873-2763, Vol. 50, nr Supplement 1, s. S67-S67 Artikel i tidskrift, Meeting abstract (Refereegranskat) Published Ort, förlag, år, upplaga, sidor 2012. Vol. 50, nr Supplement 1, s ATG was activated during osteoclast differentiation in vitro. Beclin1 was enhanced and required for osteoclast differentiation. Mechanistically, we found that TRAF6‐mediated ubiquitination of Beclin1 at K117, but not ULK1‐mediated phosphorylation, is required for RANKL‐stimulated osteoclast differentiation Reactive oxygen species (ROS) and free radicals are essential for transmission of cell signals and other physiological functions. However, excessive amounts of ROS can cause cellular imbalance in reduction-oxidation reactions and disrupt normal biological functions, leading to oxidative stress, a condition known to be responsible for the development of several diseases

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